Killing kinetics of group B streptococci for penicillin in combination with gentamicin
نویسندگان
چکیده
In vitro synergism and killing kinetics studies of penicillin in combination with gentamicin were performed with group B streptococci recently isolated in Belgium. The expected accelerated killing was not observed when compared with penicillin alone. D 2005 Elsevier B.V. All rights reserved.
منابع مشابه
In vitro bactericidal synergy of gentamicin combined with penicillin G, vancomycin, or cefotaxime against group G streptococci.
The in vitro bactericidal interactions of penicillin G, cefotaxime, or vancomycin in combination with gentamicin were compared against 20 group G streptococci by the timed kill curve method. Synergy was noted at the following frequencies: penicillin plus gentamicin, 80%; cefotaxime plus gentamicin, 85%; vancomycin plus gentamicin, 90%. There was no bactericidal antagonism observed.
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Group B Streptococcus (GBS) is increasingly causing invasive infections in non-pregnant adults. Elderly patients and those with comorbidities are at increased risk. On the basis of previous studies focusing on neonatal infections, penicillin plus gentamicin is recommended for infective endocarditis (IE) and periprosthetic joint infections (PJI) in adults. The purpose of this study was to invest...
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